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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Resveratrol, TNF-related apoptosis inducing ligand
Phytochemical Name Resveratrol (PubChem CID: 445154 )
Anticancer drug Name TNF-related apoptosis inducing ligand (PubChem CID: / )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 383
Ref_1
Pair Name Resveratrol, TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2C90.0] Renal cell carcinoma Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Activity CASP3 hsa836
Up-regulation Activity CASP9 hsa842
Up-regulation Activity CASP8 hsa841
Down-regulation Expression XIAP hsa331
In Vitro Model 786-O Renal cell carcinoma Homo sapiens (Human) CVCL_1051
OS-RC-2 Clear cell renal cell carcinoma Homo sapiens (Human) CVCL_1626
In Vivo Model These data demonstrated that RES plus Ad5/35-TRAIL significantly inhibited RCC xenograft growth in nude mice.
Result Our data demonstrated that RES plus Ad5/35-TRAIL significantly inhibited RCC xenograft growth in nude mice. These results suggest the possibility of a new combination therapeutic leading to the improvement of RCC treatment.
03. Reference
No. Title Href
1 Mechanism and therapeutic prospect of resveratrol combined with TRAIL in the treatment of renal cell carcinoma. Cancer Gene Ther. 2020 Aug;27(7-8):619-623. doi: 10.1038/s41417-019-0150-6. Click
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